Q. What are the Secretory stimuli of Somatostatin?
Ans: The secretory stimuli of Somatostatin are as follows:
- luminal nutrients.
- Gastrin, CCK, bombesin, GLP-1 (Glucagon like peptide-1), GIP(Gastric inhibitory peptide)
- Neutral influences, including PAC-AP (Pitutary adenylate cyclase – activating pepide), VIP (Vasoactive intestinal peptide) and β-adrenergic agonists stimulate while ACh (Acetyl Choline) Inihibits secretion.
Q. Name the different sources of Somatostatin and mention their functions.
- Somatostatin as the secreted by the neurosecretory neurons in the hypothalamus. It travels to the anterior pituitary gland via the portal hypophyseal blood. It inhibits growth hormone secretion from the anterior pituitary gland.
- Somatostatin is secreted by the D-cells of pancreatic islets. It acts in a paracrine fashion and inhibits secretion of insulin, glucagon and pancreatic polypeptide from the islets of Langerhan’s cells.
- Somatostatin is secreted by the D-cells in the gastro intestinal mucosa. It inhibits the secretion of G.I. hormones like gastrin, secretin, VIP, GIP and motilin.
Q. The names of Hormones of Pancreas (Endocrine).
Ans.: Insulin, Glucagon and Somatostatin.